Cleaverplas

KLKB1 is a 638 amino acids protein that belongs to the peptidase S1 family and plasma kallikrein subfamily. It contains a peptidase S1 domain and four apple domains. The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. It participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation.Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.

Store at < -20℃, stable for 6 monthshs after receipt.Please minimize freeze-thaw cycles

Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10% Glycerol,pH8.0.

Plasma kallikrein;Fletcher factor;Kininogenin;Plasma prekallikrein;KLKB1;KLK3

＜1.0 EU per µg as determined by LAL test.

＞95% as determined by reducing SDS-PAGE.

Recombinants or rec. proteins

Gly20-Ala638

recombinants

Human cells

75-87 kDa

70.2 kDa

P03952

C-6His

NA