Description

Size

100ug

Catalog no.:

GEN438283

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Specificity and cross-reactivity

It recognizes an intra-cytoplasmic antigen, which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This MAb superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Note that this MAb is not suitable for staining frozen tissues.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.

Species reactivity

Human (Homo sapiens). Does not react with Rat (Rattus norvegicus).; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

Storage and shipping

Store the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.

Properties

If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Description

For cells, cell lines and tissues in culture till half confluency.

Host organism

Mouse (Mus musculus)

Subcategory

Mnoclonal antibodies

Tested applications:

Immunohistology (IH)

Also known as

Plasma Cell Marker

Clonality

Monoclonal

Category

Antibodies

French translation

anticorps

Clone

SPM310

Immunoglobulin isotype

IgG2a

Tissue

cell

Other names

N/A

Purification method

N/A

Form/Appearance

N/A

Concentration

N/A

Other gene names

N/A

Gene name synonims

N/A

Gene name

N/A